MPF localization is controlled by nuclear export

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MPF localization is controlled by nuclear export.

In eukaryotes, mitosis is initiated by M phase promoting factor (MPF), composed of B-type cyclins and their partner protein kinase, CDK1. In animal cells, MPF is cytoplasmic in interphase and is translocated into the nucleus after mitosis has begun, after which it associates with the mitotic apparatus until the cyclins are degraded in anaphase. We have used a fusion protein between human cyclin...

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Human topoisomerase IIalpha nuclear export is mediated by two CRM-1-dependent nuclear export signals.

Resistance to chemotherapeutic drugs is a major obstacle in the treatment of leukemia and multiple myeloma. We have previously found that myeloma and leukemic cells in transition from low-density log phase conditions to high-density plateau phase conditions export substantial amounts of endogenous topoisomerase II alpha from the nucleus to the cytoplasm. In order for topoisomerase-targeted chem...

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Subcellular localization of multiple PREP2 isoforms is regulated by actin, tubulin, and nuclear export.

The PREP, MEIS, and PBX families are mammalian members of the TALE (three amino acid loop extension) class of homeodomain-containing transcription factors. These factors have been implicated in cooperative DNA binding with the HOX class of homeoproteins, but PREP and MEIS interact with PBX in apparently non-HOX-dependent cooperative DNA binding as well. PREP, MEIS, and PBX have all been reporte...

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A balance between two nuclear localization sequences and a nuclear export sequence governs extradenticle subcellular localization.

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ژورنال

عنوان ژورنال: The EMBO Journal

سال: 1998

ISSN: 0261-4189,1460-2075

DOI: 10.1093/emboj/17.14.4127